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A Genetic Mutation Causing Heart Disease in Ragdoll Cats

Jun 12, 2007
icon-blog Winn Funded Research

Meurs, K. M., M. M. Norgard, et al. (2007). "A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy." Genomics 90(2): 261-4.

Familial hypertrophic cardiomyopathy (HCM) is a primary myocardial disease with a prevalence of 1 in 500 in human beings. Heritable HCM also exists in a large-animal model, the cat, and we have previously reported a mutation in the MYBPC3 gene in the Maine coon breed. We now report a separate mutation in the MYBPC3 gene in ragdoll cats with HCM.

>> PubMed abstract

For more information:
Veterinary Cardiac Genetics lab at Washington State University
Feline Hypertrophic Cardiomyopathy
genetics hcm cat health heart hypertrophic cardiomyopathy Winn feline health Ragdoll

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