Nelson RW, Henley K, Cole C; the PZIR Clinical Study Group. Field safety and efficacy of protamine zinc recombinant human insulin for treatment of diabetes mellitus in cats. J Vet Intern Med. 2009 Jul;23(4):787-793.
This study was a prospective, uncontrolled clinical trial performed to evaluate the effects of protamine zinc recombinant human insulin (PZIR) on control of glycemia in cats with newly diagnosed or poorly controlled diabetes mellitus. One hundred thirty-three cats were enrolled in the study, consisting of 120 newly diagnosed and 13 previously treated diabetics. Cats were treated twice daily with PZIR for 45 days. Control of glycemia was assessed on days 7, 14, 30, and 45 by evaluation of changes in water consumption, frequency of urination, appetite, and body weight, serum fructosamine concentration, and blood glucose concentrations determined 1, 3, 5, 7, and 9 hours after administration of PZIR. Based on the criteria used to judge success of PZIR treatment, 113 (85%) of 133 diabetic cats, including 9 previously treated, poorly controlled diabetic cats, attained good diabetic control by day 45 of the study. Hypoglycemia (blood glucose nadir <80 mg/dL) was the only consistent problem with PZIR. The study cats also had a significant increase in mean body weight by the end of 45 days. Results of this study support using low dosages of insulin (0.22 U/kg) initially in newly diagnosed diabetic cats and adjusting the dosage of PZIR based on the response to treatment and results of blood glucose and serum fructosamine concentrations. The study supports the conclusion that PZIR is effective in controlling glycemia in diabetic cats and can be used as an initial treatment or as an alternative in poorly controlled diabetic cats that do not respond to treatment with other insulin preparations. [VT]
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protamine zinc insulin