Lingard AE, Briscoe K, Beatty JA, et al. Low-grade alimentary lymphoma: clinicopathological findings and response to treatment in 17 cases. J Feline Med Surg 2009; 11: 692-700.
Alimentary lymphoma is the most common anatomic form of lymphoma in the cats. Seventeen cats in this study were diagnosed with low-grade alimentary lymphoma (LGAL) by immunological and immunohistochemical evaluation of full-thickness biopsies collected from multiple gastrointestinal sites during exploratory laparotomy. The most common clinical signs were weight loss, inappetence, vomiting or diarrhea, vomiting and diarrhea, lethargy, and polyphagia. Vomiting and/or diarrhea were considered chronic in 11 of 15 cats. Abdominal palpation was abnormal in 12 cats. Mature neutrophilia and anemia were the most common hematological abnormalities. Serum albumin was normal in all cats tested. The most common ultrasonographic finding was normal or increased intestinal wall thickness with preservation of layering. LGAL is typically a diffuse or multifocal disease and the ileum and jejenum were most commonly affected. The cats were put on three chemotherapeutic protocols, the majority being given the oral chemotherapeutic regimen of prednisolone and high-dose pulse chlorambucil. Thirteen of the 17 cats (76%) had complete clinical remission with a median remission time of 18.9 months. Cats that were lethargic were less likely to achieve complete remission. The prognosis for cats with LGAL treated with oral prednisolone in combination with high-dose pulse chlorambucil is good to excellent. [VT]
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