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Treatment of Lymphoma in Cats

Jan 04, 2011

Gastrointestinal lymphoma is the most commonly diagnosed form of lymphoma in cats. There are two distinct forms based on size of the neoplastic lymphocytes, large- and small-cell lymphoma. This was a retrospective study of 28 cats diagnosed in large part via full-thickness intestinal biopsies with small-cell lymphoma. The majority of cases were CD3+ (T cell marker) and many exhibited epithelioltropism. In this study, all cats were started on chlorambucil at a dose of 20 mg/m2 every 2 weeks. Additionally, 17 of the 28 cats (60%) received prednisone or prednisolone at 2 mg/kg once daily for one week. All cats had their prednisone/prednisolone dosages tapered to 1 mg/kg orally every other day until disease relapse or progression of disease. Treatment with chlorambucil and a glucocorticoid resulted in clinical remission in 96% of cats, with a median duration of 786 days for the first clinical response. Seven cats relapsed from remission and were treated with a rescue protocol of cyclophosphamide and glucocorticoids. The response rate was 100% for the rescue protocol. The authors did find it striking that four (14%) of the 28 cats developed a second malignancy during their course of treatment. [VT]

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