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Cat Health News Blog

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Since its start in 2007, Cat Health News has featured the latest information on feline health. The bi-weekly blog is a mix of the most current published research from Winn-funded research and other sources. There are over 875 blog post items and more than 1,000 subscribers through the RSS feed.

icon-blogWinn-funded research is specifically noted by the small green cat.

  • DNA and feline injection-site sarcomas

    Aug 18, 2017
    Kang S, Southard T, Hume KR. DNA damage is a feature of feline injection-site sarcoma. Vet Comp Oncol. 2017 Jun;15(2):518-524

    injection site sarcomaInjection site sarcomas in cats are a serious sequela that may occur following injections such as vaccinations. These soft tissue cancers are locally aggressive, may metastasize, and are difficult to treat. Damage to DNA and the ability of a cell to repair this damage may impact the success of treatment using chemotherapy. The more damage to the DNA of the involved neoplastic cells, the more resistant to successful treatment with chemotherapy. These investigators hypothesized that injection site sarcomas may have underlying DNA damage, and that attempts by the cell to repair this damage may contribute to the resistance of some cats to chemotherapeutics.

    They assessed the presence of DNA damage in these sarcomas through evaluation of a particular protein which is made in response to DNA damage. They found that, out of 17 cats evaluated, the level of this protein varied significantly. This is a reflection of the amount of DNA damage and may explain why the efficacy of chemotherapy for injection site sarcomas varies among treated cats. They conclude that DNA damage does occur in injection site sarcomas and may contribute to the resistance of some cats to chemotherapeutic drugs. Measurement of this protein may be a useful prognostic indicator of treatment success.  (MK)

    See also:
    Martano M, Morello E, Burracco P. Feline injection-site sarcoma: past, present and future perspectives. Vet J. May;188(2):136-41.


    cancer DNA feline injection-site sarcoma Chemotherapy

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