Foust, A. L., R. Marsella, et al. (2007). "Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy." Vet Dermatol 18(4): 246-51.Microsoporum canis
is the dermatophyte most commonly associated with ringworm in cats. Several drugs have been used for treatment of M. canis
in cats, including itraconazole, griseofulvin, and terbinafine. Terbinafine (Lamisil, Novartis) is of interest because in other species, it shows good penetration into affected tissues, efficacy with short durations of treatment, and is well tolerated. Few studies have been conducted on the use of terbinafine in cats. In this study, the residual concentration of terbinafine in cat hair was determined after 14 days of oral treatment. Ten normal cats were administered terbinafine at a daily dose of 34-45 mg/kg for 14 days. Hair samples were analyzed at day 0, and weekly for 8 weeks after the last dose of terbinafine. With a 99% confidence interval, the concentration of terbinafine remained above the minimal inhibitory concentration (MIC) for 5 weeks. Four cats experienced vomiting during treatment, and two of these cats experienced intense facial pruritus 7 to 14 days after the end of treatment. The researchers concluded that terbinafine persists in cat hair at concentrations above the MIC for several weeks after the end of therapy, even when treated for only 14 days. Pulse therapy using terbinafine is worth further investigation for the treatment of feline ringworm.
>> PubMed abstractRelated articles:
Mancianti, F., F. Pedonese, et al. (1999). "Efficacy of oral terbinafine in feline dermatophytosis due to Microsporum canis." J Fel Med Surg 1(1): 37.
>> PubMed abstract
Kotnik, T. (2002). "Drug efficacy of terbinafine hydrochloride (Lamisil) during oral treatment of cats, experimentally infected with Microsporum canis." J Vet Med B Infect Dis Vet Public Health 49(3): 120-122.
>> PubMed abstract